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Dr. Manuela Ayee-Leong

Associate Professor of Engineering & Chemistry

EDUCATION & TRAINING

  • NIH Postdoctoral Fellowship, Department of Medicine, Division of Pulmonary, Critical Care, Sleep, and Allergy Medicine, University of Illinois at Chicago (UIC)
  • Ph.D., Chemical Engineering, UIC, Dissertation:
  • M.S., Chemical Engineering, Iowa State University, Thesis:
  • B.A., Engineering Science - Chemistry Emphasis, °¼Í¹ÊÓƵ (formerly °¼Í¹ÊÓƵCollege)

EXPERIENCE & INTERESTS

Dr. Ayee-Leong has experience in both academia and industry. Her research interests combine computational & experimental techniques to elucidate the molecular mechanisms underlying effects of small molecules & proteins on membrane biomechanics & cell biophysical properties, with a focus on pathogenesis. Some applications include:

  • Examining molecular interactions of myelin protein zero to uncover pathophysiological mechanisms that drive Charcot-Marie-Tooth peripheral neuropathy disease
  • Investigating modulation of cellular & tissue biomechanics by oxidized lipids & sterols under hypercholesterolemic conditions
  • Elucidating roles played by toxins in modulating properties of lipid layers

PUBLICATIONS